Genome-scale prediction of moonlighting proteins using diverse protein association information
نویسندگان
چکیده
منابع مشابه
Genome-scale prediction of moonlighting proteins using diverse protein association information
MOTIVATION Moonlighting proteins (MPs) show multiple cellular functions within a single polypeptide chain. To understand the overall landscape of their functional diversity, it is important to establish a computational method that can identify MPs on a genome scale. Previously, we have systematically characterized MPs using functional and omics-scale information. In this work, we develop a comp...
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متن کاملBioinformatics and Moonlighting Proteins
Multitasking or moonlighting is the capability of some proteins to execute two or more biochemical functions. Usually, moonlighting proteins are experimentally revealed by serendipity. For this reason, it would be helpful that Bioinformatics could predict this multifunctionality, especially because of the large amounts of sequences from genome projects. In the present work, we analyze and descr...
متن کاملWhy study moonlighting proteins?
Moonlighting proteins comprise a class of multifunctional proteins in which a single protein performs multiple physiologically relevant biochemical or biophysical functions that are not due to gene fusions, multiple RNA splice variants, or pleiotropic effects (Jeffery, 1999). Classic examples include soluble enzymes that also bind to DNA or RNA to regulate translation or transcription (Figure 1...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2016
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/btw166